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Tuesday, October 9 • 8:30am - 9:15am
Plenary Session IV: "Mechanisms Underlying Critical Periods of Brain Development: Implications for Psychiatric Disorders"

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Brain function is largely shaped by experience in early life, creating windows of both great opportunity and vulnerability. Our work has focused on the biological basis for such critical periods, identifying both “triggers” and “brakes” on plasticity. Strikingly, the maturation of particular inhibitory circuits is pivotal for the onset timing of these windows. Manipulations of their emergence can either accelerate or delay developmental trajectories regardless of chronological age. Notably, many neurodevelopmental disorders are linked to alterations in excitatory-inhibitory balance, suggesting shifted critical period timing as part of their etiology. Closure of critical periods in turn reflects an active process, rather than a purely passive loss of plasticity factors. Lifting these brakes allows the reopening of plastic windows later in life, but may also underlie instability in disease states. Thus, understanding how brain plasticity and stability are balanced throughout life offers new insight into mental illness and novel therapeutic strategies for recovery of function in adulthood.

avatar for Takao Hensch

Takao Hensch

Professor of Molecular and Cellular Biology and Professor of Neurology, Harvard University
Takao K. Hensch, PhD, is joint professor of Neurology, Harvard Medical School at Boston Children’s Hospital, and professor of Molecular and Cellular Biology at Harvard’s Center for Brain Science. He currently directs the NIMH Silvio O. Conte Center at Harvard, and conducts basic... Read More →

Tuesday October 9, 2018 8:30am - 9:15am EDT
American Ballroom Westin Copley Place, fourth floor