There are many early intervention programs around the world and most of them aim at providing specific care for the early phase of psychotic disorders. While this is a valid focus, early psychosis samples are composed of a wide variety of patient profiles and subgroups of patients may have distinct needs. Although generic elements of early intervention programs may fit most of the patients, clinicians should adapt treatment to these specific needs and develop personalized intervention. Data stemming from clinical naturalistic prospective follow-up often provide very detailed information on which it is possible to base the identification of such cinical sub-groups of patients. In this symposium we will present the results of clinical researched based on the prospective follow up of various early intervention programs in Canada, Switzerland and Australia. These data allow the identification of subgroups of patients defined on the basis of premorbid or clinical characteristic and who have specific needs in terms of clinical intervention.