IEPA 11

Donal O'Keeffe1,2, Ailish Hannigan3, Roisin Doyle1, Anthony Kinsella4, Ann Sheridan5, Aine Kelly6, Kevin Madigan4,7, Elizabeth Lawlor1, Mary Clarke1,5; 1DETECT Early Intervention in Psychosis Service, Dublin, Ireland, 2Trinity College Dublin, Dublin, Ireland, 3University of Limerick, Limerick, Ireland, 4Royal College of Surgeons in Ireland, Dublin, Ireland, 5University College Dublin, Dublin, Ireland, 6Saint John of God Hospitaller Services, Ireland, 7Saint John of God Community Services, Dublin, Ireland
               
Purpose: Although long term (8–20 year) follow ups of FEP cohorts exist; there is a paucity of very long-term (i.e. ≥ 20 years) epidemiologically representative studies of FEP incidence cohorts. While very long term data has been collected from recent onset, prevalence, first admission psychosis, and first episode schizophrenia cohorts; this research may not fully account for the heterogeneity of psychotic illness. Materials and Methods: To address these issues, we conducted a prospective 20 year follow up of a FEP incidence cohort (N=171), between 2014 and 2017, in Ireland (Irish Health Outcomes in Psychosis Evaluation - 20 year follow up: iHOPE-20). In this conference paper, we report on (i) the remission, clinical recovery, personal recovery, and resilience levels found; (ii) the interrelationship between outcomes; and (iii) baseline predictors. Results: At 20 years, we classified 20/171 cohort members (11.70%) as deceased and assessed 80/151 alive cohort members (53% recruitment rate). 65% were in remission, 35.2% were in Full Functional Recovery, and 53.7% confirmed they were fully recovered according to their personal definition of recovery. Resilience levels were markedly less than general population norms. A multifaceted interrelationship between outcomes was found. Baseline predictors varied depending on the outcome variable measured. Conclusion: Personally defined recovery and full remission in FEP is not just achievable but probable in the very long term. However, helping service users develop resilience and attain positive functional outcomes (e.g. relationships outside of family; vocational functioning/role achievement; and basic living task engagement) remain important challenges for treatment in FEP.