Hannah Jongsma1, Caitlin Turner2, Peter Jones1,3, James Kirkbride4; 1Department of Psychiatry, University of Cambridge, Cambridge, England, 2Cambridge Institute of Public Health, University of Cambridge, Cambridge, England, 3CAMEO Early Intervention Service, Cambridgeshire and Peterborough National Health Service Foundation Trust, Cambridge, England, 4PsyLife Group, Division of Psychiatry, UCL, London, England
Incidence rates of psychotic disorders are known to vary between settings. Research interest in studies investigating this has increased substantially, also outside Northwestern Europe, North America and Australia where research efforts were traditionally concentrated. It is therefore timely to synthesize incidence findings in a new systematic review and meta-analysis. We searched PubMed, PsycINFO, Embase and Web of Science databases, and included studies published between 2002 and 2017 if they reported original data on the incidence of non-organic adult-onset psychotic disorders. Quality of the yield was assessed. Data were synthesized by narrative review, and heterogeneity assessed. Data were evaluated by visual interpretation of funnel plots and univariate random-effects meta-analysis. Our search yielded 183 citations for inclusion in the review. Preliminary results suggest that heterogeneity was high: incidence of psychotic disorders varied ten-fold (incidence rates from 6.3 to 58.6 per 100,000 person-years) across settings. Incidence appeared to be higher in men (incidence rate ratio [IRR]:1.5 (95%CI:1.3-1.7), in migrants and their descendants (IRR:2.1, 95%CI:1.8-2.3) and in younger age groups. Rates of non-affective disorder varied from 1.4 to 76.7 per 100,000 person-years and followed similar demographic patterns. Rates of affective disorder varied from 0.7 to 16.9 per 100,000 person-years, and didn’t differ by sex (IRR:1.0, 95%CI:0.8-1.2). Insufficient citations were available to synthesize results by age group and migrant status. Only 23 citations were (partially) conducted in Latin and South America, Asia, Africa and the Middle East, underscoring the need to carry out research in non-Western settings. Full results will be presented at the conference.
