IEPA 11 has ended
Wednesday, October 10 • 1:45pm - 2:05pm
Symposium 23, Talk 3. "Striatal Dopaminergic Modulation of Reward Learning Predicts Daily-Life Reward-Oriented Behavior in Individuals at a Familiar Risk for Psychotic Disorder"

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Zuzana Kasanova1; 1Leuven University
Abnormalities in reward learning in psychotic disorders have been proposed to be linked to dysregulated subcortical dopaminergic (DA) neurotransmission, which in turn is a suspected mechanism for predisposition to psychosis. We therefore explored the striatal dopaminergic modulation of reward processing and its behavioral correlates in individuals at familial risk for psychosis. We performed a DA D2/3 receptor [18F]fallypride PET scan during a probabilistic reinforcement learning task in 16 healthy first-degree relatives of patients with psychosis and 16 healthy volunteers, followed by a six-day ecological momentary assessment study capturing reward-oriented behavior in the everyday life. We detected significant reward-induced DA release in bilateral caudate, putamen and ventral striatum of both groups, with no group differences in its magnitude nor spatial extent. In both groups alike, greater extent of reward-induced DA release in all ROIs  was associated with better performance in the task, as well as in greater tendency to be engaged in reward-oriented behavior in the daily life. These findings suggest intact striatal dopaminergic modulation of reinforcement learning and reward-oriented behavior in individuals with familial predisposition to psychosis. Furthermore, this study points towards a key link between striatal reward-related DA release and pursuit of ecologically relevant rewards out in the real world.


Wednesday October 10, 2018 1:45pm - 2:05pm EDT
American Ballroom-North

Attendees (8)