IEPA 11

Sofie Ragnhild Aminoff1,2, Chantal Henry3,4,5,6,7, Francesco Bettella2, Bruno Etain3,5,8, Akiah O. Berg1,2, Trine V. Lagerberg1,2, Thomas Bjella1,2, Monica Aas1,2, Srdjan Djurovic1, Frank Bellivier3,5,8, Ole A. Andreassen1,2,4, Ingrid Melle1,2; 1Oslo University Hospital, 2University of Oslo, 3AP-HP- Hôpitaux Universitaires Henri Mondor, 4ENBREC, European Network of Bipolar Research Expert Centres, 5Fondation Fondamental, 6Inserm-U955, 7Université Paris Est Créteil Val de Marne, 8AP-HP- Hôpital Fernand Widal
           
Objectives: Affective lability in bipolar disorder (BD) is a potential prodrome in at-risk youth for BD (Hafeman et al., 2016), and is present in first episode patients (Aminoff et al., 2012). It is also higher in relatives of patients with BD than in the general population (Aas et al, 2015). Affective lability has previously been shown to be associated with experiences of childhood trauma, in particular emotional abuse (Etain et al., 2017). This study aims at investigating whether affective lability also could be a part of the genetic architecture of BD. Methods: Investigate the relationship between BD polygenic risk scores (PRS), affective lability (measured by Affective Lability Scale- short from), and emotional abuse (measured by Childhood Trauma Questionnaire) in a Norwegian discovery sample (N= 82) and a French replication sample (N=259). The samples have similar proportions of BDI (78%) and BDII (22%) patients. Results: Preliminary analyses point to significant bivariate associations between affective lability and emotional abuse in both the Norwegian (rs=0.343, p=0.002) and the French sample (rs=0.302,p≤0.001). We did not find an association between BD PRS and affective lability in either sample. Conclusions: Using BD PRS we did not find support to affective lability being part of the genetic architecture of BD.